艾滋病病毒可能被“饿”死


艾滋病病毒可能被“饿”死
《青年周末》——北青子报
 
十分依赖人体供给,只要切断“粮草”


 

艾滋病病毒可能被“饿”死



一名身患艾滋病的美国男子奇迹般康复。德国柏林沙里泰医院11月11日表示,这名同时患有白血病和艾滋病的患者在接受定向骨髓移植手术20个月后,不但白血病好了,体内的艾滋病病毒也全部消失。但专家指出这名患者艾滋病病毒消失的原因尚未确定,究竟能否用骨髓移植治疗艾滋病还是未知数。另有科学家提出新思路——切断它们在人体内的供给,把它们“饿”死。这条策略之所以可行,是因为艾滋病病毒十分依赖人体细胞内的资源。

■2008年11月13日,德国血液专家吉罗·胡特召开新闻发布会宣布成功治愈一名艾滋病病人 ◎供图/IC

HIV 病毒的精明之处就在于,自打它们的遗传物质钻进人的免疫细胞,这些RNA
分子便仿照自己的模样,用我们的“建筑材料”造出一条DNA;这些DNA又太像人的遗传物质,以至于人细胞误认为这些“病毒DNA”是我们自己造的。HIV
浑水摸鱼的好日子开始了——它们不用多费心,人的细胞工厂已全面启动,按照“病毒DNA”的指令大量造出HIV 的基因和供HIV
蛋白酶剪裁的蛋白元件,再协助它们组装、出厂,以使我们免疫系统的更多细胞上当受骗。无辜的免疫系统就在不知不觉中变成了HIV
病毒的据点,不断遭到破坏,直到全面瘫痪,人就不堪一击了。
发表在2008 年1
月《科学》杂志上的一项研究显示了美国哈佛大学医学院的科学家们如何利用RNA 干涉技术使人细胞中的蛋白一个一个短路失灵,从而筛选出273
种HIV 病毒生存所必需的人细胞蛋白。这273 种人类蛋白被统称为HIV
依赖因子。它们在细胞的各个角落和细胞活动的各个环节行使功能,研究人员发现,这些被检测命中的“病毒依赖因子”恰好在免疫系统细胞中含量很高,怪不得免疫系统细胞偏偏是HIV
病毒的最爱。
HIV
病毒想要存活下去必须大量偷用我们的蛋白,这正给我们留下了反攻的余地。如果科学家能够使HIV依赖因子失灵,那么任凭病毒再怎么突变也无法从这种药物眼下蒙混过关。
◎据新浪科技、《新知客》杂志等综合报道

AIDS virus may be "starved" dead
"Young people over the weekend" - Green-North newspaper

Very dependent on the supply of the human body, cut off as long as the "food"


AIDS virus may be "starved" dead


A man suffering from AIDS in the United States miraculous recovery. Bolin Sha Thai hospital in Germany on November 11, said this at the same time suffering from leukemia and AIDS patients receiving bone marrow transplants targeted 20 months after the leukemia is not only good, the body of the AIDS virus also be lost. However, experts point out that the disappearance of HIV patients is not known yet, whether by bone marrow transplantation in the treatment of AIDS is still uncertain. Another scientist proposed new ideas - they cut off the supply in the human body, they are "hungry" to die. This strategy was possible because the AIDS virus in human cells is dependent on resources.

■ 2008 years 11 13, Germany's guiro Huth blood experts held a news conference that the success of a cure for AIDS patients ◎ map / IC

HIV virus of the wise is that the Government giving the their genetic material into human immune cells, the RNA
Who will follow their appearance, we used the "construction materials" to create a DNA; these people too much like DNA and genetic material that cells were mistaken for the "virus DNA" of our own making. HIV
The good days started to fish in troubled waters - they do not have to worry about, the human cells, plant fully operational, in accordance with the "virus DNA" instructions to create a large number of HIV genes and for HIV
The protein proteases cut components, to help them re-assembled, factory, so we have more of the immune system cells taken. Innocent on the immune system unknowingly become HIV
The virus stronghold, the destruction continued until paralyzed in a single blow on the people.
Published in 2008 1
On "Science" magazine of a study in the United States at Harvard Medical School scientists how to use RNA interference technology is a protein in the cells of a short-circuit failure, which screened 273
Types of HIV virus necessary for the survival of human cell protein. This 273 kinds of human protein known as HIV
Dependence factor. In every corner of the cell and cell activity in the various segments of the exercise of functions, the researchers found that the detection of these hit the "virus-reliance on" just in the cells of the immune system in high concentration, no wonder the immune system cells, but HIV is
Virus favorites.
HIV
Viruses want to survive, we must use to steal a large number of proteins, which are left room for a counter-offensive. If scientists can make HIV-dependent failure, then they are allowed to have mutations in the virus no matter how the drug can not get away now.
◎ Sina, according to science and technology, "new clients" of the magazines roundup