Scientists in the monkeys who make AIDS treatment success of the test
At 9:37 on December 15, 2008 Source: Sohu Science
【Sohu scientific According to Russian news link News Network reported that scientists have recently found success in the monkeys carried out the treatment of AIDS tests. Experiment, scientists suffering from AIDS in monkeys injected with a body of a monoclonal antibody that effectively curbed monkeys who develop symptoms of AIDS, to receive the experimental treatment is also Macaque no more obvious side effects.

The experiment involved in the United States of Atlanta University researchers said the treatment of AIDS overall goal is to suppress the virus and enhance immune function and overall health. HIV infection in the human body, and damage to major violations of human immune cells such as T helper cells (T), monocytes and macrophages, and so on, because of T helper cells have a receptor HIV, it is vulnerable to HIV and T cells Combination. HIV in the growth and reproduction of these cells, cell damage and lead to the total number of lymphocytes, leading to significantly reduce the number of T cells, T / Ts (suppression of T cells) to reduce the ratio, the lower immune function. Cellular immunity when a serious defect performance for the full range of skin tests with the lack of response, lymphocyte transformation rate, serious opportunistic infections and tumors, and so on. At

The experimental treatment, they first of all to make a monkey infected with the AIDS virus similar to the simian immunodeficiency virus. Then, the researchers infected monkeys who had a four monoclonal antibody injection to inhibit or block the monkeys in the body's immune receptor PD-1. The study found that in HIV or hepatitis C patients, the immune PD-1 receptor may inhibit the body in patients with a variety of cell immune response. The researchers said that as long as immune receptor blocking PD-1, will be able to upgrade the T-cell immunity, thereby enhancing the immune system in patients with HIV's ability to resist and ultimately to patients with weakened immune to kill the virus. The researchers found that the monoclonal antibodies have not received the injection in monkeys infected with HIV virus in the body after 15 months there have been further development of the situation, and accepted the monoclonal antibody injection of monkeys, the virus in the body's development has been inhibited, in good health .

Previously, researchers had done in mice similar to the experimental HIV treatment, but the results can not be satisfied with the researchers. This is because rats are rodents, these animals are not the most ideal experimental HIV treatment of animal models. Infected with simian immunodeficiency virus (SIV) in monkeys and its pathogenesis of HIV infection in the pathogenesis similar to human, immunodeficiency virus infection in monkeys is the study of AIDS pathogenesis and to develop anti-AIDS drugs and vaccines for HIV, as well as in vivo treatment The best experimental model.

The researchers stressed that the monoclonal antibody injections may cause more significant immune response. However, the treatment of monkeys in the experiment did not find any obvious reaction and anomalies. Accordingly, the researchers expressed the hope that as soon as possible on the human body in a similar experimental treatment of AIDS, and eventually developed a more effective treatment for AIDS drugs. Currently, the United States to deal with the use of monoclonal antibody immune receptor PD-1 treatment has entered the stage of clinical trials. Medarex U.S. biotechnology company said they have begun to try compensation method for the treatment of chronic hepatitis C. (Li Shang)