研究显示牙周炎可能会激活潜伏的艾滋病病毒
2009年02月11日 16:30:33 来源：新华网
新华网东京２月１１日电（记者钱铮）日本的一项研究显示，当人们患牙周炎时，牙周炎病原菌产生的丁酸有可能激活潜伏的艾滋病病毒，促使艾滋病发病。
据日本《每日新闻》１１日报道，日本大学教授落合邦康和名古屋市立大学教授冈本尚等人进行了相关研究。此前有研究显示，潜伏在免疫细胞中的艾滋病病毒的增殖在一种名为组蛋白去乙酰化酶的物质的作用下被抑制，一旦这种酶的作用受到阻碍，病毒就变得活跃，受感染者就会发病。另一方面，牙周炎病原菌在增殖过程中制造出大量丁酸，检测表明，牙周炎患者牙齿和牙龈之间的缝隙中丁酸的含量是健康人的２０倍到３０倍。
落合邦康等人研究了丁酸和组蛋白去乙酰化酶之间的相互作用。他们把潜伏有艾滋病病毒的免疫细胞放入含有丁酸的牙周炎病原菌培养液，结果证实艾滋病病毒迅猛增殖。由此，研究人员证实了丁酸可以抑制组蛋白去乙酰化酶，而因牙周炎大量产生的丁酸的确可以借此激活潜伏的艾滋病病毒。
据报道，２５岁以上的日本人中８０％以上患有不同程度的牙周炎，而日本也有不少艾滋病病毒携带者。落合邦康教授表示，那些并没有意识到自己感染艾滋病病毒的人，可能会因为患牙周炎而发病。今后研究人员打算通过动物实验和流行病学调查来证实这一点。
曾有报告说牙周炎和糖尿病以及心脏疾病相关，而本次研究结果表明牙周炎还可能会激活潜伏的艾滋病病毒。此间专家表示，这个结果或许会成为人们重新认识保持口腔清洁重要性的契机。
Studies have shown periodontitis may activate latent HIV
February 11, 2009 16:30:33 Source: Xinhuanet
Xinhua Tokyo, February 11 (Xinhua Qian Zheng), a Japanese study showed that when people suffering from periodontitis, the periodontal pathogens have generated acid may activate latent HIV to AIDS.
According to Japan's "Daily News" reported on the 11th, the Japanese University professor B. K. Ochiai and Nagoya City University, Professor Okamoto, who is still carried out related research. Prior research has shown that hidden in the immune cells in the proliferation of HIV in a so-called histone deacetylase effects of the material was inhibited, once the role of this enzyme have been hampered, the virus becomes active, by incidence of infection will be. On the other hand, the proliferation of periodontal pathogens in the process of manufacturing large quantities of butyric acid, testing showed that patients with periodontitis teeth and gums in the gap between the content of butyric acid is a healthy person 20 times to 30 times.
B. K. Ochiai and others studied the acid and histone deacetylase interaction. They have latent HIV immune cells Add periodontitis pathogenic bacteria containing acid culture medium, the results confirmed the rapid proliferation of HIV. Because of this, the researchers confirmed that butyrate can inhibit histone deacetylase, and because a large number of generated acid periodontitis can indeed take the activation of latent HIV.
It is reported that more than 25 years of age in more than 80% of Japanese suffer from varying degrees of periodontitis, while Japan also has a lot of people living with HIV. Professor B. K. Ochiai said that those who are not aware of their HIV infection, and may be suffering from periodontitis and incidence. The researchers next plan to animal experiments and epidemiological investigations to confirm this.
Had reported that periodontitis and diabetes and heart disease-related, and the results of this study showed that periodontitis may also activate latent HIV. Experts here said that the results will become a new awareness of the importance of maintaining oral hygiene opportunities.