From food of plant research and development of new drugs to treat AIDS三合saponins
Liu said, according to the inventor: food plants from the research and development of new drugs to treat AIDS Kang Sheng Dan 〔tentative name, chemical name: Sanhe〕 saponins from three scientific combination of saponin.
Saponins, also known as saponin or saponin is a steroid or triterpenoid compounds collectively oligosaccharide glycosides, which in aqueous solution to form a durable foam, the same name as the soap, it widely exists in plants and marine animals.
More than the chemical composition of the major pharmacological effects: 1. Immune regulatory function. To enhance the role of T cells, in particular, the enhanced T cell function, can make IL-2 (IL-) secretion to increase, while the function of IL-2 can protect the T cell survival and reproduction. The promotion of T cells to produce lymphokines, and enhance cell Traps NK (natural killer cell) differentiation. Enhance the LAK (lymphokine-activated killer cells) activity, and thus organisms showed strong immune function. 2. Anti-tumor effects. ① to kill tumor cells have a direct role and growth inhibition. ② combination with the bile acid can form large mixed micelles, thereby preventing the occurrence of colon cancer. ③ to prevent the proliferation of epithelial cells, so that the normalization of proliferative cells, which play the role of anti-tumor cells. 3. Anti-virus anti-HIV effect. Biological research can prove that inhibition of plaque formation of HIV drugs, so that the protection of cellular immunity has been disorderly, and then kill HIV. 4. Anti-oxidation, anti-free radical and anti-coagulation, anti-thrombotic, anti-diabetes. By increasing the SOD (superoxide dismutase) content, reducing LPO (LPO), scavenging free radicals and reduce the role of free radical damage and promote repair. Can reduce the x-ray-induced damage probability of genetic material, can reduce the radiation of a hydrolysis product of free radicals, accelerate the metabolism of free radicals into the indirect effects, LPO is a free radical metabolites. Can inhibit platelet aggregation, and reduce fibrin, but also can inhibit the in vivo toxicity index of cohesion from the role of fibrin, and can inhibit thrombin-induced fibrin thrombus formation. Can inhibit fibrinogen conversion to fibrin, can reduce blood sugar, the rate of platelet cohesion, there are anti-diabetic effect.
On drug-related study is still continuing and look forward to the successful development of more patients to benefit.
Attachment:
Saponins (saponins), also known as saponin, is widely present in plants of a special class of glycosides, and its aqueous solution can produce long-lasting after振摇soap bubble-like, hence the name.
After hydrolysis in accordance with saponin Sapogenins generated structure can be divided into triterpenoid saponins (triterpenoidal saponins) and steroidal saponins (steroidal saponins) two broad categories. Saponin composition of common sugar glucose, galactose, rhamnose, arabinose, xylose and glucuronic acid, galacturonic acid, etc., are often associated with C3 Sapogenins-OH-bit connection into effect.
Pharmacological effects of ginsenosides
1. Immunoregulatory role of two-way;
2. Anti-hypoxia and anti-fatigue effect;
3. The role of anti-low-temperature stress;
4. Anti-lipid peroxidation;
5. The role of the central nervous system;
6. Anti-mutagenesis;
7. The adjustment of the kidney, kidney.