Kang Sheng Dan summed up with the western medicine treatment of AIDS

Concord out-patient department experts 〔Xianyang, Shaanxi, 710063〕
Wang Xiaojun张颖强Sun Jun杨启哲
Director: Liu

Abstract: This paper and the various complications of AIDS treatment drugs, as well as the specific Kang Sheng Dan, San saponin treatment of the importance of the whole; guide AIDS patients a comprehensive treatment of science; and AIDS for the ultra-high heat or heat lead to fungal infections has done a detailed breakdown reference.
Key words: AIDS Kang Sheng Dan saponins三合rehabilitation treatment

Acquired Immune Deficiency Syndrome, or AIDS, the acronym AIDS; due to human immunodeficiency virus 〔〕 HIV infection referred to as a result of a variety of complicated infections, chronic consumption, complicated with tumor and organ failure and high mortality rates against the world's intractable infectious diseases. I疰drugs based on traditional Chinese medicine within the knot with虚损win disease pathogenesis, such as analysis of traditional Chinese medicine, developed by Kang Sheng Dan family medicine in order to effect a significant and short-term patients with advanced western medicine, which rapidly easing, reducing the return to work; Today, we summarize this as follows:
Asymptomatic HIV-infected persons
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Sustained systemic lymphadenopathy
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Amoxicillin 2 ~ 4 / time, 3 times / day, oral;
Metronidazole 4 ~ 6 / time, 3 times / day, oral;
Ping Xiao 6 ~ 8 tablets / time, 3 times / day, oral.
Of oropharyngeal candidiasis (thrush)
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Local drug therapy
(1) 2% ~ 4% sodium bicarbonate solution: for breast-feeding before and after washing the mouth, to eliminate acid to decompose residual rennet or carbohydrate, so that the mouth to become alkaline environment, can prevent the growth of Candida albicans and reproduction . No other drugs in children with mild, lesions in the 2 ~ 3 days to disappear, but will continue to use a few days to prevent recurrence. The drug can also be washed before and after breast-feeding nipple in order to avoid cross-infection or repeated infection.
(2)甲紫aqueous solution: oral mucosa in order to appropriate concentration with 0.5%,涂搽3 times a day to treat infants and young children thrush and angular cheilitis.
(3) Chlorhexidine: 0.12% solution or gel l% partial coating, rinse or gargle, it can be combined into a nystatin ointment or cream, of which amount of triamcinolone acetonide may be added to the treatment of angular cheilitis, denture stomatitis go far (cream can be applied to surface wear base entrance in the organization). With chlorhexidine solution and sodium bicarbonate solution alternately toilet can be coordinated to eliminate the pathogen Candida albicans - Gram-negative bacteria.
Antifungal treatment
(1) nystatin: 50000 ~ local available 100,000 U / ml of water suspension coating, 2 ~ 3 hours each time, after the coating can be ingested. Gargle mouthwash agents can also be used, or made into tablets, emulsions and so on. Children (1 to 2 years old) oral 100,000 U / times, 3 times a day; adult oral 500,000 ~ 1,000,000 u / times, 3 times a day.
(2) squint and Culture triazole: oral mucosa can be used in powder, cream applied to glossitis and angular cheilitis, treatment is generally on the 10th.
(3) Fluconazole: for a new type of broad-spectrum antifungal agents and efficient. Adult first-dose 200mg / d, after 1 day, each 100mg, treatment for at least 2 weeks.
(4) of the fluconazole-resistant infections can choose to use itraconazole therapy, 100mg / d, treatment for 10 ~ 14 days.
Comprehensive treatment
In addition to use of antifungal agents, and the frail, with immune deficiency disease or related diseases and chronic systemic Candida infection in patients with: often need to be complemented by enhanced immunity of comprehensive treatment measures, such as injection of transfer factor, thymosin, LPS and so on, added iron, vitamins and so on.
Surgical treatment
For candidal leukoplakia in mild, moderate epithelial dysplasia, with more than drug treatment (treatment of up to 3 to 6 months), may be reversed or disappeared. Precancerous lesion such treatment should be strictly observed to spot changes, periodic review, if the treatment effect was not obvious or can not be tolerated in patients with drug therapy, surgical resection should be considered.
Recurrent or persistent poor response to treatment of vulvovaginal candidiasis
Wash genital hip bath or 1:5000 potassium permanganate solution, partial solution coated 2% gentian violet. In recent years, the application of the system fungal (nystatin) significant effects. Usage: 100,000 U vaginal suppository morning and evening of the 1st, deep into the vagina, a total of 5. Wash the vulva, local涂搽nystatin ointment (100,000 U / g) 2 ~ 3 times / d. After the treatment of vaginal epithelium in order to promote regeneration, a small amount of estrogen can be used ( Effects of acid had been en-0.25 ~ 0.5mg / day, 3 to 5 days).
Intravenous infusion of 0.5% levofloxacin 250 ml of sodium chloride per day / time, once a 7. From oral to light.
Persistent diarrhea / chronic cryptosporidiosis enteritis
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Amoxicillin 2 / time, 3 times / day, oral;
Metronidazole 4 / time, 3 times / day, oral;
Berberine 4 / time, 3 times / day, oral.
Light more than 3 days of basic rehabilitation; heavy intravenous medicine to cope with the efforts:
5% G • S 250 ml + gentamicin 120,000 U 1 times / day;
5% metronidazole injection 250 ml 1 times / day.
Chronic cryptosporidiosis enteritis see diffuse or extra-pulmonary disease of Coccidioides immitis pneumonia in the treatment of drug use.
Complicated by herpes zoster
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Neurotrophic oral or intramuscular vitamin B, such as B1: 100mg, B12: 250vg, or B1, mecobalamin, such as 250-500vg.
Anti-virus
Famciclovir Tablets Famciclovir Tablets, 0.125g; oral, 8 hours 1.
Valaciclovir, 300 mg, oral; 2 times / day.
Acyclovir, 200 mg; oral; 5 times / day.
Polyinosinic cells, 2 mg; intramuscular injection; 1 / 2.
Interferon, 3 million U; intramuscular injection; 1 times / day.
Pain
Oral analgesic to pain pills and other tablets.
Ibuprofen (Fenbid) 300 mg orally 2 times / day.
Morphine controlled-release tablets, 30 mg; if necessary, oral.
Closure of the spine adjacent to the treatment of ganglion.
Hormone
Early oral prednisone to reduce inflammation and pain, to prevent the occurrence of postherpetic neuralgia have a certain effect.
9,966,331 program (prednisone 45 mg 2 days, 30 mg 2 days, 15 mg 2 days, 5 mg 1 day).
Topical treatment of early erythema blister may be convergence of drugs for external use, such as calamine lotion;
There is erosion, necrosis, can profit by 0.1% for wet rivanol liquid, topical antibiotic ointment.
Rifampicin film protection, anti-bacterial effect.
Net ocular herpes eye drops, antibiotic eye ointment treated.
Acyclovir ointment 3-4 times daily Tu affected area.
Ultraviolet radiation physiotherapy, to promote the absorption of inflammation, to reduce the role of the course. The latter can be used for infra-red neuralgia, such as audio-frequency electric therapy.
Polygonum perfoliatum collecting their broken up, choose juice mixed with equal cinnabar, apply mature lesion. This method for the Taiwanese folk medicine, effective, about a week to recover.
Of idiopathic thrombocytopenic purpura
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Methylprednisolone intravenous needle 5 ~ 10mg/kg/d replaced by 3 ~ 7d after prednisone tablets 1mg/kg/d points 2 or 3 times the oral, the maintenance of 1 week (and for the light condition and platelet> 50 × 109 / L will be able to direct oral prednisone tablets, usage ibid.), after a week when by 5 ~ 20mg instead of every 2 to 3 weeks by 5mg, to the maintenance of 5 ~ 10mg when 6 to 12 months;
New Neoral capsules, the initial dose of 5 ~ 10mg/kg / d (sub-2, q 12h), adjust the dose to the effective maintenance of plasma concentration after 4 to 6 weeks; vincristine (VCR) 1 ~ 2mg / times 1 times a week at most 4 to 6 times;
At the same time, intravenous hemostatic, anti-inflammatory drugs may be appropriate.
Ultra-high heat or heat treatment
Emergence of clinical disease in patients with high fever, or ultra-high heat, most of the body temperature at 39 or 42 degrees between the clinical treatment of difficult, many doctors or hospitals are unable to persuade them to return home and self-cultivation; waiting patients will be increasingly suffering from weight loss, fever extraordinary; coma syncope not provincial personnel, medical treatment may not be, wronged died.
My clinical years, the use of western medicine with Kang Sheng Dan achieved effect. Drugs are as follows:
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral.
Detection of fungal infection in vivo and more, such as Penicillium and other rare fungal infection. Fungi classification system of human knowledge and history of the use of fungi in the West have been more than in 3500, China has 6000 years. The emergence of fungal taxonomy and development is in the last 200 years. 1729, Mikkeli (Micheli) observed with a microscope study of the first fungi, fungi raised keys. In 1735, Linnaeus in the "natural system" and so the book will be divided into 10 genera of fungi. Above is the starting point for classification of fungi, some are set at the time were still in use. In 1772, Linnaeus "binomial" the adoption of the taxonomy of fungi played an enormous role in promoting. In a very long period of time, according to the first two Linnaean Definition, fungi have been included in Flora. Modern taxonomists have tended to be fungi into a single sector - fungal community (KingdomFungi), fungi in the community under the door and the door Myxomycetes. Scholars in the history of different points of view in accordance with their respective number of the classification system established in the last 30 years there have been more than 10 new classification system. A few influential classification system such as: besse (1950) fungal community will be divided into categories Myxomycetes, algae-like bacteria gang, gang ascomycetes, Basidiomycetes and semi-known mycetes. Whitaker (1969) in the community set up under the three sub-sectors: the bare sub-sector bacteria, double flagellin sub-sector, the fungal sub-sector; in the fungi under the sub-sector has set up branches after the flagellum and flagellar branch; in the latter branch Zygomycetes to draw a door, door ascomycetes and basidiomycetes door. Ainsworth (Ainsworth, 1971,1973) of the classification system established under the sector in the two fungi: Fungi Myxomycetes doors and doors. Unlike in the past, he will be further divided into algae-like fungi and bacteria to flagellum Zygomycetes, fungi belonging to the original outline of the door a few in the subglottic upgraded to sub-door, five sub-gate: cotina flagella, Zygomycetes Asia doors, door ascomycetes Asia, Basidiomycotina known and semi-cotina. Margulies (1974) Myxomycetes of the classification system for the sector excluded from the fungi, will be included lichens, located directly in the sector Zygomycetes door, door ascomycetes, basidiomycetes door, semi-known lichen fungi and bacteria door door . Alex索普罗斯(Alexo-poulos) (1979) fungal community will be divided into bacteria door naked (that is, the door Myxomycetes) and fungi door, which is in turn divided into flagellated bacteria door (at a single flagellum cotina, two flagella cotina), non-flagellated bacteria door (sub-sub-Zygomycetes door, door ascomycetes Asia, Basidiomycotina, semi cotina know).阿尔克斯(1981) will be classified predecessors cotina flagella (Principal) made some type of independent, will upgrade to the door, the establishment of Myxomycetes doors, door pot bacteria, fungi Oomycete doors and doors; doors in fungi draw six Class: Class Zygomycetes, the key link in Neurospora crassa, Jiao mycetes, ascomycetes Gang, Basidiomycetes and semi-known mycetes. Classification systems have a number of reasons, the scholars consider the relationship of fungi, the useful criteria to evaluate a number of different. An ideal classification system should be able to accurately reflect the natural relationship of fungi and evolutionary trends. In the current classification system has been in many, there is not a recognized by the world and determine a reasonable classification system. Multiple classification system in comparison, the majority of people think that Ainsworth and Alex索普罗斯more comprehensive two-person system, close to reasonable, but also reflect the content of new progress has been more and more people acceptable. Ainsworth will be divided into 5 sub-fungal door door, 18-gang, 68 head.
Marneffei infection such as clinical disease efficacy of the use of ketoconazole in Iraq not only a bad song, but serious complications such as jaundice, abnormal liver function, severe hepatic encephalopathy caused 〔〕 hepatic coma, such as organ failure, will died, is very dangerous situation. We switch to amphotericin b, conventional dosage is 20 to 30 mg / day / time intravenous drip, the use of 3 days there is abnormal liver function, jaundice and other side effects; to 5 ~ 10 mg / day / time intravenous drip, extend the treatment to 15 ~ 30 days. Dan Kang Sheng at this time of patients with immune-induced memory T cells not to be too low to alleviate and eventually recovered and were discharged home to continue oral therapy Dan Kang Sheng, a case of 15 years were found to be well so far.
External physical methods such as cold dry ice, alcohol外搽, water bath, etc.; may be served at the same time, such as traditional Chinese medicine生石膏,水牛角or horn, to really Dan, Dan, such as the crown.
Diffuse or extra-pulmonary disease of Coccidioides immitis pneumonia
At this point the main plane感染灶pneumonia combined protozoan adenovirus, Mycobacterium tuberculosis infection in patients with rapid short-term cough, expectoration, bleeding, difficulty in breathing, shortness of breath, chest tightness, chest pain restrain inflation, mixed with fat, such as severe chest irritation; At the same time, complicated by high fever. Improper treatment at this time, or can not control will also lead to death. Contact the author of such patients with more advanced cases, the use of combination therapy of Chinese and Western, is hereby introduced as follows:
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral;
Malaria treatment should include the treatment of patients is now (to kill Plasmodium falciparum erythrocyte-stage) and telogen attack of malaria treatment (to kill red blood cells outside the sub-period of dormancy). The treatment of telogen is the resting period of malaria transmission, to 1 ~ 2 years of malaria history and treatment with insects to control the recurrence of vivax malaria and reduce the source of infection.
By anti-malarial drugs on Plasmodium view the role of different insects can be divided into red blood cells outside the period of crack to kill daughters and son of the anti-dormancy drug relapse, such as primaquine quinoline; kill crack erythrocyte precursors of the anti-proliferative Clinical drug seizures, such as chloroquine, pyronaridine (pyronaridine), artemisinin (artmisinin) category and kill mosquito sporozoite inhibit the proliferation of drugs in vivo spores, such as pyrimethamine.
Of patients are used chloroquine Garber quinoline ammonia for the treatment of malaria among suspected malaria patients; resistant vivax malaria relapse (telogen treatment) can be used quinoline plus primaquine pyrimethamine, artesunate ammonia Garber better quinoline; Plasmodium falciparum chloroquine can be single-serving, anti-Plasmodium falciparum chloroquine combination therapy are advised, such as piperaquine plus sulfadoxine (sulfadoxine), pyronaridine plus sulfadoxine and primaquine quinoline, compound Artemisia films such as dimethyl ether, alone artesunate, artemether, dihydroartemisinin also have a certain effect; severe malaria (eg cerebral malaria) of choice for artemisinin-based drugs such as artemether oil injection, sodium intravenous artesunate, or intravenous plus two Dihydroartemisinin quinoline hydrochloride; In addition, artemisinin suppository drugs can not be applied to patients with oral drugs. The above anti-malarial drugs and services must be fully adequate way to reach the objective of malaria eradication.
Caused by adenovirus infection complications
Such as the liver and spleen lymph nodes outside the viral cytomegalovirus, cytomegalovirus retinitis treatment lead to blindness are as follows:
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral;
Aciclovir 4 / time, 3 times / day, oral;
Ganciclovir 20 mg +5% G • S infusion, 1 second / day. In severe cases, use of oral medication, while light can be.
Kaposi's sarcoma, Burkitt lymphoma, the immune cell lymphoma, primary brain lymphoma
Reference to the principles of cancer treatment, we must first take or the San Tan Kang Sheng saponins a course〕 〔3 months after the side for safe and effective; and full with good treatment effect.
Pneumocystis carinii pneumonia, recurrent pneumonia
Dan Kang Sheng three particles per day 2 to 4 bags, oral;
〔Saponins三合Kang Sheng Dan〕 four generations of chemical drugs, 3 times / day, 2 ~ 4 / day, oral;
Treatment for pathogens. Previously used Formamidine pentane (pentamidine isothionate) 100 ~ 150mg / (m2 • d) or 4 ~ 5mg / (kg • d), intramuscular injection of 10 ~ 14 days. Inhalation also, early use of the drug, at least 60% of patients can be cured, but about half heavier children may be adverse side-effects occurred, such as aseptic abscess, rash, hypotension, nausea, vomiting, vertigo, hypoglycemia, hypocalcemia, giant anemia, thrombocytopenia, neutropenia and hepatic and renal function damage. At present, the preferred drug for Trimethoprim (TMP) 20mg / (kg • d) plus Sulfamethoxazole (SMZ) 100mg / (kg • d), sub-2 services, and even served two weeks, and its effect with n-pentane Formamidine similar, but far more rare adverse side-effects, manifested as allergic skin reactions and gastrointestinal tract. Also advocated SMZCo100mg / (kg • d) 2 weeks after the half and then reduced to two weeks, then reduced to 1 / 4 the volume of use together in February, the effective rate was 75% of the drug as a chemopreventive agent, in the application of immunosuppressant in the prevention of high-risk children with the disease, the dose of TMP5mg / (kg • d) and SMZ25mg / (kg • d), both sub-2 oral or even the service three days a week, stopping four days, once a 6 months.
Supportive therapy, including intramuscular injection of gamma globulin or placental globulin, can enhance the immune system. Oxygen if necessary. Such as in the use of corticosteroids occurred in the course of the disease, it would take to reduce or stop. For the prevention of the disease in high-risk cross-infection in children, recently advocated the implementation of respiratory isolation until the end of treatment. Poor prognosis. Foreign reports mortality 10% ~ 50%, an average of 40%. However, recently, that a timely manner by the active treatment, the cure rate can be as high as 70%.
HIV-related encephalopathy, progressive multifocal leukoencephalopathy lesions
Reference to the treatment of related diseases, clinical treatment of disease is very difficult there,九死一生. As long as effective control of other related complications, the above probability is very low there.
Previously, I have put forward in 2005, the treatment of AIDS to the "infection", "immune," "nutrition" three related, but also the essence of treatment on AIDS therapy and academic summary; someone will propose: Why do you have to take the whole treatment The two drugs you do? Kang Sheng Dan三合because saponins and inventor Professor Liu Jun 〔〕 major pharmacological effects: 1. Immune regulatory function. To enhance the role of T cells, in particular, the enhanced T cell function, can make IL-2 (IL-) secretion to increase, while the function of IL-2 can protect the T cell survival and reproduction. The promotion of T cells to produce lymphokines, and enhance cell Traps NK (natural killer cell) differentiation. Enhance the LAK (lymphokine-activated killer cells) activity, and thus organisms showed strong immune function. 2. Anti-tumor effects. ① to kill tumor cells have a direct role and growth inhibition. ② combination with the bile acid can form large mixed micelles, thereby preventing the occurrence of colon cancer. ③ to prevent the proliferation of epithelial cells, so that the normalization of proliferative cells, which play the role of anti-tumor cells. 3. Anti-virus anti-HIV effect. Biological research can prove that HIV drugs inhibit the formation of plaque, so that the protection of cellular immunity has been disorderly, and then kill HIV. 4. Anti-oxidation, anti-free radical and anti-coagulation, anti-thrombotic, anti-diabetes. By increasing the SOD (superoxide dismutase) content, reducing LPO (LPO), scavenging free radicals and reduce the role of free radical damage and promote repair. Can reduce the x-ray-induced damage probability of genetic material, can reduce the radiation of a hydrolysis product of free radicals, accelerate the metabolism of free radicals into the indirect effects, LPO is a free radical metabolites. Can inhibit platelet aggregation, and reduce fibrin, but also can inhibit the in vivo toxicity index of cohesion from the role of fibrin, and can inhibit thrombin-induced fibrin thrombus formation. Can inhibit fibrinogen conversion to fibrin, can reduce blood sugar, the rate of platelet cohesion, there are anti-diabetic effect.
Kang Sheng Dan三合known saponins and major chemical components were saponins (saponins), also known as saponin, is widely present in plants of a special class of glycosides, and its aqueous solution can produce long-lasting after振摇soap bubble-like , hence the name. After hydrolysis in accordance with saponin Sapogenins generated structure can be divided into triterpenoid saponins (triterpenoidal saponins) and steroidal saponins (steroidal saponins) two broad categories. Saponin composition of common sugar glucose, galactose, rhamnose, arabinose, xylose and glucuronic acid, galacturonic acid, etc., are often associated with C3 Sapogenins digital connection into the-OH glycosides. Pharmacological effects: the role of bi-directional immune; anti-hypoxia and anti-fatigue effect; the role of anti-low-temperature stress; anti-lipid peroxidation; on the role of the central nervous system; anti-mutagenic effect.
In addition, clinical application has so far in 2002, over a thousand cases of proven efficacy; a major role in the AIDS disorder of immune memory T cells to enhance the protection induced by CD4, biological inhibition, killing 〔HIV human immunodeficiency virus and the role of short〕 at all applicable types of complications.
                          July 18, 2009 Saturday
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