瑞士日内瓦大学研究人员8日在其发表的一项研究成果中宣布，他们成功复制了一种南美猴子体内具有抗艾滋病毒功能的基因，这将可能为一种新型艾滋病疗法的诞生铺平道路。
当天发表在《临床调查学报》电子版上的这项研究成果称，研究人员成功复制了猫头鹰猴（owl monkey）体内抗艾滋病毒基因后，将其植入
与人类免疫学特征相同的转基因老鼠体内，发现该基因仍具有与原基因相同的抗艾滋病毒的能力。
该研究小组负责人卢班教授表示，这种基因的成功复制表明它将有可能作为现有抗艾滋病毒药物的替代手段，用作艾滋病基因治疗。
生活在南美洲的猫头鹰猴体内这种有抗艾滋病功能的基因，是卢班教授2004年带领美国哥伦比亚大学的一组科学家发现的。
3.中国发现三种皂甙可从T细胞途径杀灭艾滋病
本站讯2009年9月10日中医药疑难病专治网
刚刚从中国某军事医学研究院传出消息，中国科研人员刘君等从数种食物与中药中科学分离提取成功三种从T细胞途径杀灭HIV的三种自然有机皂甙，预示其将有望成为新的免疫疗法治疗艾滋病的新药。
他们发现的新物质目前已经成功合成暂定名为三合皂甙的新药，在初步的HIV动物体内模型与临床观测的十余例患者中显示奇特疗效∶从T细胞结合的三种有机皂甙化学成分分析为人体必须的糖原有机物，直接以营养T细胞的特定机理结合在人体免疫的重要细胞--T细胞内核，发挥营养T细胞的作用；同时，诱导激活免疫应答反应，生物性抑制HIV毒癍再形成，逐步性的分解、清除感染在血液中的HIV病毒；并使HIV在治疗中与结合的T细胞基因变异为正常细胞，伪装性的分离HIV基因片段，从而科学治疗艾滋病。
随后的进一步研究将揭晓此项研究更为科学的治疗艾滋病机理。
Three open a new dawn of AIDS Research
1. The study said differences in incidence of AIDS among women and men are expected to bring new therapies (Figure)
At 09:24 on September 10, 2009 Source: Science Times Qunfang
Now scientists have proved that men and women in the development of HIV huge differences exist in the process.
Now scientists have proved that good men and women in the development process of HIV great difference, that is, the rate of growth of women to AIDS significantly faster than males carrying the same virus. U.S. scientists have now pointed out that this may be partly due to plasma cell-like dendritic cells caused by differences in immune response between the sexes due.
Plasmacytoid dendritic cells in immune activation is considered to play a key role, they can take advantage of pathogen recognition receptors - including the Toll-like receptor 7 (TLR7) - to perceive the virus RNA, and the subsequent secretion of cytokines , for example, interferon-α (IFNα) and tumor necrosis factor. Immune activation is considered to effectively predict the progress of HIV disease, so in vitro, as from the AIDS virus by the various ligands stimulated Angela Meier Harvard University and others by the plasma cells, dendritic cell-secreted cytokines were analyzed. Interestingly, with plasma cells from the male-like dendritic cells, compared to using TLR7 ligand stimulation, from the women's plasma cell-like dendritic cells can produce more of IFNα, which means that HIV infection by cytokine secretion caused by the existence of significant gender differences.
By CD8 + T cells - an important predictor of disease progression, researchers found that secretion of IFNα were able to increase CD38 expression. Consistent with this, CD38 expression levels in the female body was significantly higher than males.
In the end, in order to find out whether their observations apply to in vitro, the researchers analyzed the long been infected with HIV and have not received prior treatment for men and women in T-cell activation level. In fact, after adjusting for the baseline, after carrying the virus, there is activity of CD8 + T cells in the percentage of women to be significantly higher than males.
The researchers pointed out that these findings suggest that the response to HIV compared with men, plasma cells, dendritic cells in the female body to produce more IFNα, resulting in higher levels of CD8 + T-cell activation. The researchers believe that this enhanced immune activation may be able to explain the women observed the same level of HIV viral replication caused by a more rapid progression of the disease, also showed that regulate TLR7 signal path may be a promising AIDS treatment method. The researchers recently published "Nature - Medicine" magazine reported on the research results.
(Editor: Xu Jing-hui)
2. Scientists from the monkeys to copy the success of anti-HIV gene
Xu Fu's published Time :2009-09-10 11:00:56 International Online
Geneva, Switzerland 8 University researchers published a study in its results, announced they succeeded in copying the body of a South American monkeys with anti-HIV function of genes, which may be the birth of a new AIDS therapies pave the way for.
The same day, published in the "Journal of Clinical Investigation" e-version on the results of the study, said researchers have successfully copied the owl monkey (owl monkey) in vivo anti-HIV genes, will be implanted in
The same characteristics with the human immunodeficiency transgenic mice and found that the gene still has the original genes, the ability of anti-HIV.
The research team leader Professor Lu Ban said the success of the gene shows that it will be possible to copy an existing anti-HIV drugs as an alternative means of gene therapy for AIDS.
Living in the South American owl monkeys in vivo function of such kind of anti-HIV genes, is Professor Lu Ban 2004 Columbia University, led a group of scientists found.
3. China has found three saponins from the T-cell pathway to kill HIV
Powered hearing in September 2009 10 Japan-China Medical difficult disease cures Network
Just from China, came news of a military medical research institute, China's Liu and other researchers from several kinds of food and medicine in the separation of science from the T-cell extract three kinds of ways to kill HIV, three kinds of natural organic saponins, indicating that it will likely become the a new immune therapy of AIDS drugs.
They found that the new substance has tentatively successfully synthesized a new drug for the triple saponin, in the preliminary animal model of HIV and clinical observation more than ten patients, showed peculiar effect: From the T-cell combination of three kinds of organic chemical composition analysis of saponins necessary for the human body glycogen organic matter, nutrients directly to the specific mechanism of T-cell immunity in the body with important cell - T-cell core, nutrition, T cells play a role; the same time, activate the immune response induced by biological inhibition of HIV drug Ban re-formation, a gradual decomposition, clear the infection in the blood of the HIV virus; and to HIV in treatment with combination of T-cell gene mutation of normal cells, and camouflage of the separation of HIV gene fragments, which the scientific treatment of AIDS.
Further study will be announced later this study the mechanism more scientific treatment of AIDS.
