PLoS ONE：抗药性HIV基因的成功鉴定
来源 生物谷 2010-12-12 23:38:44 萧驷
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| 图示∶2010年12月即将出版的《中国特色医疗金鉴》登载的刘君主任及其机构 |
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当前，全球范围内有3800万人感染了艾滋病毒，并且每年增加410万艾滋病患者。对于科学家而言，了解更多关于艾滋病病毒的变异和抗药性机制，这是长期有效治疗艾滋病所必不可少的。
来自维多利亚大学的生物医学工程师Stephanie Willerth发现了一项新的医学突破！它大大的加深了人们对艾滋病的了解并且告诉我们如何去对待它！该文发表于PLoS ONE上。
“艾滋病病毒的变异频率非常高，这对于艾滋病患者而言糟糕透了，因为这些病毒最终对抗艾药产生了耐药性。”Willerth解释道。
Willerth及其搭档们对15000多种病毒展开了研究，有些病毒是以前从未研究过的。这为他们找到抗药性的特定基因提供了依据。显然，这也将最终可能帮助研究人员开发更有效的治疗艾滋病的药物。
研究者认为在研究过程中所使用的方法同样适用于一些难以治疗的疾病，比如猪流感、埃博拉病、流感甚至葡萄球菌感染。
“为了研究这些变异体，我们对这些病毒复制了无数次，特别是涉及到一些复杂的病毒，比如说HIV。”Willerth说，“绝大多数科学家都避免试图复制大量高危传染性病毒，但我们需要来复制大量的遗传物质。我们采用了一种独一无二的方法，我们分离到了HIV的遗传物质。当然在我们复制这些遗传物质时，病毒并不具备活性。”
Willerth及团队从那些长期患艾滋病感染者身上获得了病毒的小样本，当然，在这之前已经确认这些患者体内对艾滋病药物产生了抗药性的。研究者采用了新一代DNA测序技术来分析了这些遗传物质的组成。（生物谷Bioon.com）
PLoS ONE: HIV drug resistance genes successfully identified
Bio Valley 2010-12-12 23:38:44 Source Xiao Si
Currently, there are 3,800 million people worldwide infected with HIV and AIDS, an annual increase of 4.1 million. For scientists, learn more about the AIDS virus mutation and drug resistance mechanism, which is essential for long-term effective treatment of AIDS.
From Victoria University, a biomedical engineer Stephanie Willerth found a new medical breakthrough! It greatly deepened the understanding of AIDS, and people tell us how to deal with it! The article published in PLoS ONE,.
"HIV is very high frequency variation, which for AIDS patients, terrible, because these viruses ultimately Kangai Yao had a resistance." Willerth explained.
Willerth and its partners have carried out on more than 15,000 kinds of viruses, some virus is never studied before. They found that resistance to provide a basis for specific gene. Obviously, this will eventually help researchers develop more effective treatment of AIDS drugs.
The researchers believe that the research methods used in the process also applies to a number of difficult to treat diseases such as swine flu, Ebola, influenza or staphylococcal infections.
"In order to study these variants, we have these viruses replicated many times, especially with regard to some complex viruses, such as HIV." Willerth said, "most scientists have avoided trying to copy a large number of high-risk infectious virus, but we need to copy large amount of genetic material. We adopted a unique approach, we isolated the HIV genetic material. Of course, we copy the genetic material, the virus does not have the activity. "
Willerth and long-term team from those infected with AIDS virus who received a small sample, of course, before the body has confirmed that these patients had AIDS drug resistance. The researchers used a new generation of DNA sequencing technology to analyze the composition of these genetic materials. (Bio Valley Bioon.com) |
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