同时患艾滋病和白血病的美国男子骨髓移植后“起死回生”变异基因打开“抗艾”新思路 康生丹因免疫调控治疗艾滋病
日期:2010-12-18 作者:叶松亭 来源:文汇报
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图示∶2010年12月即将出版的《中国特色医疗金鉴》登载的刘君主任及其机构 |
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近日,一则消息轰动了国际艾滋病学界:一名同时患有艾滋病和急性白血病的中年美国男子,在2007年接受了骨髓造血干细胞移植手术后,不仅治愈了白血病,体内的艾滋病毒竟也全部消失。专家们认为,虽然骨髓移植风险巨大,病例中所使用的办法目前还无法推广,但这一“特例”为学界提供了新的研究思路。
据柏林研究人员发表在最新一期学术期刊《血液》上的文章,这名美国男子“起死回生”的关键在于他所接受的来自他人的骨髓造血干细胞。为这名美国男子提供干细胞的捐赠者,体内携带一种罕见的变异基因,这种变异基因能够为人体提供针对艾滋病毒的天然抵抗力。
这种名叫“德尔塔32”的变异基因,可以在大约1%的欧洲人体内找到,能够阻止人体内的CCR5蛋白出现在细胞膜表面。由于艾滋病毒需要通过CCR5蛋白才能侵入细胞内部,因此,在有“德尔塔32”存在的人体内,艾滋病毒就无法感染细胞。正是“德尔塔32”逼使这名美国男子体内的艾滋病毒“无用武之地”。
英国诺丁汉大学教授鲍尔表示,其实研究人员早于10年前就已知晓了这一抗病毒原理,“但这是第一次将原理变成现实”。而澳大利亚国家艾滋病流行病学与临床研究中心负责人多诺万教授提醒说:“干细胞移植是一种高端且昂贵的治疗方法,目前我只推荐那些同时患有白血病和艾滋病的病人使用这种治疗方法,无法保证对每名艾滋病患者都有效。” 本报见习记者 叶松亭
新闻点评∶源于以上研究的证实,免疫恢复是康复艾滋病的根本。刘君教授发明的治疗艾滋病新药康生丹系列产品,自1993年科研至2002年临床应用以来,在激活免疫应答反应系统与提升患者CD4、杀灭HIV等药理作用下,拯救了无数的患者生命;不也是免疫造福患者的佐证吗?
刘君 协和专家门诊部艾滋病治疗中心主任、教授、专家,中医药疑难病专治网站长等。论文《艾滋病中医论治探析》登载《中国性病艾滋病》2003版杂志,发明的艾滋病治疗新药康生丹自2002年临床应用至今疗效显著,现有中国唯一艾滋病新药3代--康生丹颗粒、4代康生丹--三合皂甙胶囊〔中药化学单体提取99.99%〕对外服务;治疗咨询15809294481〔业务繁忙短信约定为先〕。
At the same time suffering from AIDS and leukemia after bone marrow transplantation American men "back to life" mutated gene open the "anti-AIDS" new ideas Kang Sheng AIDS treatment for immune regulation
Date :2010-12-18 of: Ye Songting Source: Wen Wei Po
Recently, a news sensation in the international AIDS community: one with AIDS and acute leukemia, while middle-aged American man, in 2007, received a bone marrow hematopoietic stem cell transplantation, not only cured the leukemia, the body of HIV, had all disappear. Experts believe that, although the risk of bone marrow transplantation huge case approach used in the present can not promote, but this "special case" for academic provides a new idea.
According to the researchers in Berlin, published in the latest issue of journal "Blood" on the article, this U.S. men "back to life," the key is that he accepted from the bone marrow hematopoietic stem cells of others. For the provision of a U.S. man, donor stem cells, the body carried a rare gene variant, this variant can be provided for the human body's natural defenses against HIV.
This is called "Delta 32" gene variation, you can in about 1% of Europeans find the body, the body can prevent CCR5 protein in the cell membrane surface. Because CCR5 protein of HIV need to be penetrated inside the cells, therefore, the "Delta 32" exists in the human body, HIV can not infect cells. It is "Delta 32" to force the body of a U.S. man of HIV, "useless."
Professor at the University of Nottingham, said Powell, in fact, researchers have known as early as 10 years ago this anti-virus principle, "but this is the first time the principle into reality." The Australian National HIV Epidemiology and Clinical Research Center, Professor Donovan cautioned that: "Stem cell transplantation is a treatment for high-end and expensive, now I only recommend those that AIDS patients suffering from leukemia and use of this treatment, can not guarantee is valid for each AIDS. "newspaper trainee reporter Ye Songting
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Liu Jun Union experts director of the Center AIDS treatment clinics, professors, experts, Chinese medicine and long difficult disease cures website. Paper "on the Treatment of AIDS medicine," published in "China STD & AIDS" 2003 version of the magazine, Kang Sheng invented the AIDS treatment drug clinical application since 2002, has a significant effect, the only current generation of AIDS drugs 3 - Kang Sheng particles, 4 on behalf of Kang Sheng - triple saponin monomers of Chinese medicine extract capsules 〔〕 99.99% of foreign services; treatment business consulting 15809294481 〔〕 busy message for the first contract.
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