美国戴维斯生医光电科技中心的研究团队首次利用高速3D扫描显微摄影机技术记录了艾滋病病毒的传播过程。这项新的突破将会使艾滋病防治技术产生质的飞跃。
研究人员利用一种荧光的水母蛋白标志艾滋病病毒，一旦携带有艾滋病病毒的T细胞靠近正常细胞，该细胞内的艾滋病病毒蛋白就会在几分钟之内入侵临近健康细胞。T细胞是人体内主要的免疫细胞，同时也是艾滋病病毒主要的攻击对象。影像显示带有荧光标志的艾滋病毒在入侵临近的健康细胞时，两个细胞之间形成一种桥梁，叫做滤过性微生物突触。艾滋病病毒之所以能够在细胞间扩散，大多是由于艾滋病病毒受体细胞与正常细胞的这种接触。汤姆斯博士说，“这一发现解释了为何多年来研制抗艾滋病毒的工作不成功的原因。只有了解了病毒传播的模式，我们才更有可能研制出阻止艾滋病毒扩散的办法。”美国西奈山医学院的助理教授本杰明说，“T细胞之间通过滤过性微生物突触感染艾滋病毒是细胞间高效传播这种病毒的主要途径。”本报综合报道屈亚媛
Record the first time scientists image the process of the spread of HIV
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2009/03/29 04:10:00 Source:华商网- China Daily
The United States Davis Biomedical Optoelectronic Technology Center research team first high-speed 3D scanning micro-camera technology records the spread of HIV. This new breakthrough in AIDS prevention and control will make a qualitative leap in technology.
The researchers used a fluorescent jellyfish protein markers of the AIDS virus, once carrying the AIDS virus around the T cells and normal cells, the cells of the AIDS virus protein would be invaded within a few minutes near the health cells. Human T cells are the main immune cells in vivo, but also the major HIV target. With fluorescence imaging showed signs of HIV in the invasion of neighboring healthy cells, the two form a bridge between cells called synapses microorganisms filtration. The reason why HIV can at cell proliferation, mostly because of AIDS virus receptor cells and normal cells of such contacts. Dr. Tang Musi said, "This discovery explains why for many years to develop the work of anti-HIV causes of failure. Only by understanding the virus transmission mode, we have developed are more likely to prevent the spread of HIV approach." The United States Sinai Hill School of Medicine Assistant Professor Benjamin said, "T cells of micro-organisms through filtration synaptic cells infected with HIV are between the efficient dissemination of the main ways the virus." newspaper reported that General Qu Yuan Asia
