AIDS, the importance of immune reconstitution is the fundamental life-saving
"AIDS 28 years ago the discovery, research and treatment, from cocktails to the combination therapy, T cell immune reconstitution of great significance; charged with saving lives, protect the health and survival of a major extension of the mission." Kang Sheng Dan Ⅱ type of four generations of new drugs - San saponin Mr. Liu Jun inventor with emotion to tell people so.
The first reaction of the immune response to the resumption of immunization, CD4 and T cells will be included in AIDS treatment, research and clinical statistics of scientific research work is Dan Kang Sheng January 6, 2000 declaration of the Chinese drug scene at the time of invention patents.
Kang Sheng Liu Dan as the outcome of AIDS research and media attention has been raised is the matter in 2003, more than six years ago. Six years, Kang Sheng Dan from the initial generation, the second generation to third-generation - Kang Sheng Dan particles, as well as the new fourth generation of chemical second-class drugs - saponin三合; experienced a lot of hard work exploration, and gradually found the chemical active ingredients -- three types of saponin, the HIV virus and its complications, such as starting with the reorganization of the immune response from immunization, the protection of T cell disorder, biological and human immunodeficiency virus drugs inhibit the formation of plaques, to kill HIV; effective prevention science AIDS.
Saponins (saponins), also known as saponin, is a steroid or triterpenoid compounds collectively oligosaccharide glycosides is widely present in plants of a special class of glycosides, and its aqueous solution can produce long-lasting after振摇kind of soap bubble, hence the name. After hydrolysis in accordance with saponin Sapogenins generated structure can be divided into triterpenoid saponins (triterpenoidal saponins) and steroidal saponins (steroidal saponins) two broad categories. Saponin composition of common sugar glucose, galactose, rhamnose, arabinose, xylose and glucuronic acid, galacturonic acid, etc., are often associated with C3 Sapogenins-OH-bit connection into effect.
Inventor Liu Declaration: Kang Sheng Dan三合saponins Class Ⅱ four generations of chemical drugs pharmacological action of the chemical composition of the principal: 1. Immune regulatory function. To enhance the role of T cells, in particular, the enhanced T cell function, can make IL-2 (IL-) secretion to increase, while the function of IL-2 can protect the T cell survival and reproduction. The promotion of T cells to produce lymphokines, and enhance cell Traps NK (natural killer cell) differentiation. Enhance the LAK (lymphokine-activated killer cells) activity, and thus organisms showed strong immune function. 2. Anti-tumor effects. ① to kill tumor cells have a direct role and growth inhibition. ② combination with the bile acid can form large mixed micelles, thereby preventing the occurrence of colon cancer. ③ to prevent the proliferation of epithelial cells, so that the normalization of proliferative cells, which play the role of anti-tumor cells. 3. Anti-virus anti-HIV effect. Biological research can prove that inhibition of plaque formation of HIV drugs, so that the protection of cellular immunity has been disorderly, and then kill HIV. 4. Anti-oxidation, anti-free radical and anti-coagulation, anti-thrombotic, anti-diabetes. By increasing the SOD (superoxide dismutase) content, reducing LPO (LPO), scavenging free radicals and reduce the role of free radical damage and promote repair. Can reduce the x-ray-induced damage probability of genetic material, can reduce the radiation of a hydrolysis product of free radicals, accelerate the metabolism of free radicals into the indirect effects, LPO is a free radical metabolites. Can inhibit platelet aggregation, and reduce fibrin, but also can inhibit the in vivo toxicity index of cohesion from the role of fibrin, and can inhibit thrombin-induced fibrin thrombus formation. Can inhibit fibrinogen conversion to fibrin, can reduce blood sugar, the rate of platelet cohesion, there are anti-diabetic effect.
At the same time, more than drug therapy in the clinical trial showed that patients with some strange effect: After patients with rapid control of infection, the rapid growth of body weight, evidence of life gradually improved, cocktail treatment or have to adapt to the gradual reduction or discontinuation. Therefore, immune reconstitution Liu, director of the AIDS advocacy continued CD4, T cells after another academic advocate; For more progress will be in the future new study reports. Wang Xiaojun 2009. 06.22.