艾滋病和结核病双重感染之谜初步揭开

艾滋病和结核病双重感染之谜初步揭开
2009年07月02日 10:13:45 　来源：新华网
新华网华盛顿７月１日电（记者任海军）美国哈佛大学医学院一项最新研究显示，艾滋病病毒携带者之所以易感染结核杆菌，是因为病毒破坏了人体抵抗结核杆菌的防御体系，这对预防艾滋病和结核病双重感染的研究具有重要意义。

研究人员将健康人与尚未出现结核病症状的艾滋病病毒携带者进行对比研究发现，两者的肺泡巨噬细胞存在差异，艾滋病病毒携带者的对结核杆菌的免疫反应水平较低。

研究人员随后采取了艾滋病病毒携带者的肺部样本，发现其中一种名为ＩＬ－１０的分子水平有所升高。肺泡巨噬细胞抵抗结核杆菌的能力降低，正是ＩＬ－１０增多的结果，因为它导致肺泡巨噬细胞中蛋白质ＢＣＬ－３量减少。

这项研究成果刊登在新一期《白细胞生物学杂志》上。该杂志副主编约翰·惠里认为，艾滋病病毒和结核杆菌是人类在公共卫生领域面临的严峻挑战，二者结合后危害性尤其严重，哈佛大学的研究增进了人类对这种双重感染的了解。

世界卫生组织的相关资料显示，并发结核病是艾滋病患者死亡的常见原因。

AIDS and tuberculosis infection in the mystery of double the initial kick
July 2, 2009 10:13:45 Source: Xinhua
     Xinhua Washington, July 1 (Xinhua Ren Navy) to a recent Harvard Medical School study shows that the reason why HIV susceptible TB because HIV undermines the body's defense system of Mycobacterium tuberculosis resistance, which the prevention of AIDS and tuberculosis research dual infection is important.

     Researchers have not yet appeared healthy people with symptoms of TB compared with HIV found that both alveolar macrophages are different, people living with HIV for TB in a lower level of immune response.

     The researchers then taken of the lungs of people living with HIV samples and found one called the IL-10 increased the molecular level. Alveolar macrophage's ability to reduce the resistance of Mycobacterium tuberculosis, IL-10 increase is the result, because it resulted in alveolar macrophages of protein BCL-3 reduced.

     The results of the study, published in the new issue of "Journal of Leukocyte Biology" on. Deputy editor of the magazine that John Hui years, HIV and TB is the human face in the field of public health challenges, in particular, a combination of both after the danger of serious study at Harvard University to promote the human understanding of this dual infection.

     World Health Organization data show that patients with AIDS complicated by tuberculosis is a common cause of death.