HIV outer sugar chain structure of the unique For the development of AIDS vaccine provides a new idea Published: 2010-07-24 | author: Hai-Ying Liu http://www.stdaily.com 2010 年 07 月 24 First Stage: Journal of Science and Technology: Hai-Ying Liu Newspaper in London on July 22 (Xinhua LIU Hai-ying), University of Oxford website has issued a press release, the school led by an international team of researchers found that AIDS virus (HIV) the outer wrapping of the sugar chain structure and very unique stability, which is completely different from other body cells. The researchers pointed out that this feature can be used to develop new AIDS vaccine, so that the immune system can recognize volatile HIV, and combating infection. From Oxford University, California, Scripps Research Institute and the Massachusetts Institute of Boston researchers Ragon, an international research team, from different parts of the world's HIV were analyzed. They have a variety of HIV-1 live virus samples were separated from carbohydrates layer (sugar) in its chemical structure analysis found that the sugar exists in all the HIV-1 virus and its evolutionary branches, its structure is unique, and other human cells in different forms of sugar.
The researchers also found that the current development of AIDS vaccines and HIV in the sugar structure of the sugar structure is different, and may cause these vaccines can not be completely simulated HIV.
Led the study, University of Oxford 克里斯斯坎 Lunbo Shi pointed out that the virus, closely wrapped in sugar-coated outer layer is called "carbohydrate mask layer", because the sugar chain and human cells look the same as the outer sugar chain, the general and difficult to be immune system recognition. The new findings suggest that, HIV this camouflage is defective, HIV on the sugar specificity may provide an opportunity to attack the virus. Vaccine formulations set a dangerous signal to force the immune system of the sugar structure of this particular attention to identification of HIV. Dr. Scanlon said some of the development of cancer vaccines is to use this approach.
Dr. Scanlon noted, HIV is extremely variable, an HIV virus infection in vivo changes in one day than the entire UK a change of influenza virus influenza season even more. Variability of this virus for the development of an AIDS vaccine is not a small challenge. The outer sugar chain found in the particularity of HIV will help to find a new method of developing an AIDS vaccine.
The research published in the latest issue of "U.S. National Academy of Sciences" on.
