在美会议深入研讨基因疗法治愈艾滋病病例
2011年10月10日06:28来源:中国科普网
9月17-20日,第51届抗微生物制剂及化疗跨学科国际会议(ICAAC)在美国芝加哥市举行。会议深入研讨了基因疗法治愈艾滋病及取得显著成效的几个病例,展示了医学界攻克艾滋病的最新研究成果。
德国柏林人Timothy Brown是迄今世界上唯一一位被治愈的艾滋病患者。Brown感染艾滋病病毒后患上了白血病。医生采取的治疗方法是给他换血,所换血液来自一位血液中T细胞的受体基因CCR5存在先天缺陷的供体。CCR5正是艾滋病病毒入侵到细胞内部的必经途径。经过一段时间的治疗,Brown痊愈了。
美国的几位医生采用上述思路对15位艾滋病病人进行了治疗。医生们取出病人血液中的T细胞,请加州桑加莫(Sangamo)生物科技公司用锌指核酸酶(Zinc Finger Nuclease Enzyme)对这些T细胞进行处理使它们的CCR5失效,然后把产生的约100亿个此类T细胞输回病人体内。医生们的检测发现约25%的T细胞产生了失效的CCR5,它们在一些病人体内抵抗艾滋病病毒的感染达6个月之久。
一些与会科学家们说这些研究成果令人兴奋,表明人类离攻克艾滋病又近了一步。






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图示∶2011年5月正式出版的《中国特色医疗金鉴》登载的刘君主任及其机构事迹 |
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Depth discussion in the United States Conference of gene therapy to cure AIDS cases
At 06:28 on October 10, 2011 Source: China science network
17-20 September, 51st Antimicrobial Agents and Chemotherapy interdisciplinary and international meetings (ICAAC) held in Chicago in the United States. Meeting in-depth discussion of gene therapy to cure AIDS and achieved remarkable results in several cases, showing the medical profession to overcome the latest AIDS research.
Timothy Brown Berlin, Germany is by far the only one to be cured of AIDS. Brown, after HIV infection suffering from leukemia. Medical treatment is taken to his shake-up, the exchange of blood from a blood T-cell receptor gene CCR5 donor birth defects exist. CCR5 is the AIDS virus to the cell interior a necessary way. After a period of treatment, Brown recovered.
Several U.S. doctors use these ideas for 15 AIDS patients were treated. Doctors remove the patient's T cells in the blood, please California Sangamo (Sangamo) biotechnology company with a zinc finger nuclease (Zinc Finger Nuclease Enzyme) treatment of these T cells fail to make their CCR5, and then produce about 100 one hundred million of these T cells transferred back to the patient. Doctors testing found that about 25% of T cells to produce a failure of CCR5, which in some patients the body against HIV infection up to 6 months.
Some scientists say the meeting exciting results of these studies, indicating that the human AIDS, from the capture is a step closer.
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